Home Task 20-2

Task 20-2

Critical Appraisal of Practice Guidelines

The purpose of this assignment is to apply findings from evidence-based practice and research to enhance practice guidelines and health care outcomes.While there are several tools available for evaluating practice guidelines, the most comprehensively validated appraisal tool is the AGREE II Instrument. This tool can be used both by individual practitioners to critically appraise health guidelines and by decision makers to inform policy decisions. The purpose of the AGREE II Instrument is to provide a framework for assessing the quality of guidelines, present a methodological strategy for developing guidelines, and inform what/how information should be reported in the guidelines.The AGREE II Instrument examines the following six domains relevant to the practice guideline being assessed:Domain 1: Scope and Purpose

Domain 2: Stakeholder Involvement
Domain 3: Rigor of Development
Domain 4: Clarity of Presentation
Domain 5: Applicability
Domain 6: Editorial Independence

In addition to each of the six domains, the tool also includes a space for rating the overall quality of the practice guideline to determine whether it should be recommended for use in practice.Criteria are rated on a 7-point scale from 1 (Strongly Disagree) to 7 (Strongly Agree). A rating of 1 is given when there is no information relevant to an item, the item is poorly reported, or it is explicitly stated that the criteria is not met. A rating between 2 and 6 is given when the item as reported does not fully meet the criteria. A rating of 7 is given when the quality of reporting is excellent, and the full criteria have been met. Further rating explanations can be found in the User’s Manual section of the AGREE II Instrument resource.

For this assignment, choose an evidence-based practice guideline relevant to your DPI project or chosen area of study. Refer to the “Evidence-Based Guidelines” study material for websites where a specific guideline can be identified for the purposes of this assignment or select a guideline of your own choosing.

General Requirements:Use the following information to ensure successful completion of this assignment.

Doctoral learners are required to use APA style for their writing assignments. The APA Style Guide is located in the Student Success Center. An abstract is not required.

Directions:
Perform the following tasks to complete this assignment:

1. Provide a link to your selected guideline and explain why you chose it, supporting your response with an explanation of why you selected it.
2.Using the AGREE II Instrument User’s Manual for reference, complete the “DNP-820 AGREE II Instrument Table” template for your chosen guideline.(SEE Attached)
3. Include comments after each domain to support your rationale for providing the rating you chose and include any considerations that influenced your rating decision. Cite all sources referenced.

Critical

Appraisal of Practice Guidelines

The purpose of this assignment is to apply findings from evidence

–

based practice and

search to

enhance practice

guidelin

es and health care outcomes.

While there are several tools available for evaluating practice guidelines, the most comprehensively

validated appraisal tool is the AGREE II Instrument. This tool can be used both by individual practitioners

to critically appraise health guidelines and by

decision makers to inform policy decisions. The purpose of

the AGREE II Instrument is to provide a framework for assessing the quality of guidelines, present a

methodological strategy for developing guidelines, and inform what/how information should be

ported in the guidelines.

The AGREE II Instrument examines the following six domains relevant to the practice guideline being

assessed:

Domain 1: Scope and Purpose

Domain 2: Stakeholder Involvement

Domain 3: Rigor of Development

Domain 4: Clarity of Presen

tation

Domain 5: Applicability

Domain 6: Editorial Independence

In addition to each of the six domains, the tool also includes a space for rating the overall quality of the

practice guideline to determine whether it should be recommended for use in practic

Criteria are rated on a 7

–

point scale from 1 (Strongly Disagree) to 7 (Strongly Agree). A rating of 1 is

given when there is no information relevant to an item, the item is poorly reported, or it is explicitly

stated that the criteria is not met. A rati

ng between 2 and 6 is given when the item as reported does not

fully meet the criteria. A rating of 7 is given when the quality of reporting is excellent, and the full

criteria have been met. Further rating explanations can be found in the User’s Manual se

ction of the

AGREE II Instrument resource.

For this assignment, choose an evidence

–

based practice guideline relevant to your DPI project or chosen

area of study. Refer to the “Evidence

–

Based Guidelines” study material for websites where a specific

guidelin

e can be identified for the purposes of this assignment or select a guideline of your own

choosing.

General Requirements:

Use the following information to ensure successful completion of this assignment.

Doctoral learners are required to use APA style for

their writing assignments. The APA Style

Guide is located in the Student Success Center. An abstract is not required.

This assignment uses a rubric. Please Review the rubric prior to the beginning to become

familiar with the expectations for successful com

pletion.

· You are not required to submit this assignment to LopesWrite.

Directions:

Perform the following tasks to complete this assignment:

· Provide a link to your selected guideline and explain why you chose it, supporting your response with an explanation of why you selected it.

· Using the AGREE II Instrument User’s Manual for reference, complete the “DNP-820 AGREE II Instrument Table” template for your chosen guideline.

· Include comments after each domain to support your rationale for providing the rating you chose and include any considerations that influenced your rating decision. Cite all sources referenced.

Critical Appraisal of Practice Guidelines

The purpose of this assignment is to apply findings from evidence
–
based practice and research to
enhance practice guidelines and health care outcomes.

While there are several tools available for evaluating practice guidelines, the most comprehensively
validated appraisal tool is the AGREE II Instrument. This tool can be used both by individual practitioners
to critically appraise health guidelines and by

decision makers to inform policy decisions. The purpose of
the AGREE II Instrument is to provide a framework for assessing the quality of guidelines, present a
methodological strategy for developing guidelines, and inform what/how information should be
re
ported in the guidelines.

The AGREE II Instrument examines the following six domains relevant to the practice guideline being
assessed:

Domain 1: Scope and Purpose

Domain 2: Stakeholder Involvement

Domain 3: Rigor of Development

Domain 4: Clarity of Presen
tation

Domain 5: Applicability

Domain 6: Editorial Independence

In addition to each of the six domains, the tool also includes a space for rating the overall quality of the
practice guideline to determine whether it should be recommended for use in practic
e.

Criteria are rated on a 7
–
point scale from 1 (Strongly Disagree) to 7 (Strongly Agree). A rating of 1 is
given when there is no information relevant to an item, the item is poorly reported, or it is explicitly
stated that the criteria is not met. A rati
ng between 2 and 6 is given when the item as reported does not
fully meet the criteria. A rating of 7 is given when the quality of reporting is excellent, and the full
criteria have been met. Further rating explanations can be found in the User’s Manual se
ction of the
AGREE II Instrument resource.

For this assignment, choose an evidence
–
based practice guideline relevant to your DPI project or chosen
area of study. Refer to the “Evidence
–
Based Guidelines” study material for websites where a specific
guidelin
e can be identified for the purposes of this assignment or select a guideline of your own
choosing.

General Requirements:

Use the following information to ensure successful completion of this assignment.

Doctoral learners are required to use APA style for
their writing assignments. The APA Style
Guide is located in the Student Success Center. An abstract is not required.

This assignment uses a rubric. Please Review the rubric prior to the beginning to become
familiar with the expectations for successful com
pletion.

Critical Appraisal of Practice Guidelines

The purpose of this assignment is to apply findings from evidence-based practice and research to

enhance practice guidelines and health care outcomes.

to critically appraise health guidelines and by decision makers to inform policy decisions. The purpose of

the AGREE II Instrument is to provide a framework for assessing the quality of guidelines, present a
methodological strategy for developing guidelines, and inform what/how information should be

reported in the guidelines.

The AGREE II Instrument examines the following six domains relevant to the practice guideline being

assessed:

Domain 1: Scope and Purpose

1. Domain 2: Stakeholder Involvement

2. Domain 3: Rigor of Development

3. Domain 4: Clarity of Presentation

4. Domain 5: Applicability

5. Domain 6: Editorial Independence

In addition to each of the six domains, the tool also includes a space for rating the overall quality of the

practice guideline to determine whether it should be recommended for use in practice.

Criteria are rated on a 7-point scale from 1 (Strongly Disagree) to 7 (Strongly Agree). A rating of 1 is

given when there is no information relevant to an item, the item is poorly reported, or it is explicitly

stated that the criteria is not met. A rating between 2 and 6 is given when the item as reported does not

fully meet the criteria. A rating of 7 is given when the quality of reporting is excellent, and the full

criteria have been met. Further rating explanations can be found in the User’s Manual section of the

AGREE II Instrument resource.

For this assignment, choose an evidence-based practice guideline relevant to your DPI project or chosen

area of study. Refer to the “Evidence-Based Guidelines” study material for websites where a specific

guideline can be identified for the purposes of this assignment or select a guideline of your own

choosing.

General Requirements:

Use the following information to ensure successful completion of this assignment.

 Doctoral learners are required to use APA style for their writing assignments. The APA Style

Guide is located in the Student Success Center. An abstract is not required.

 This assignment uses a rubric. Please Review the rubric prior to the beginning to become

familiar with the expectations for successful completion.

APPRAISAL OF GUIDELINES

FOR RESEARCH & EVALUATION II

INSTRUMENT

___________________________________________________________________________________

The AGREE Next Steps Consortium
May 2009

UPDATE: December 201

This document is the product of an international collaboration.
It may be reproduced and used for educational purposes,

quality assurance programmes and critical appraisal of
guidelines. It may not be used for commercial

purposes or product marketing. Only approved non-English
language versions of the AGREE II Instrument should be used,

where available. Offers of assistance in translation into other
languages are welcome, provided they conform to the

protocol set out by The AGREE Research Trust.

DISCLAIMER
The AGREE II Instrument is a generic tool designed primarily to

help guideline developers and users assess the
methodological quality of guidelines.

The authors do not take responsibility for the improper use of
the AGREE II Instrument.

SUGGESTED CITATION FOR AGREE II PUBLICATION
Brouwers MC, Kho ME, Browman GP, Burgers JS, Cluzeau F, Feder G, Fervers B, Graham ID, Grimshaw J, Hanna

SE, Littlejohns P, Makarski J, Zitzelsberger L, for the AGREE Next Steps Consortium. AGREE II: Advancing guideline
development, reporting and evaluation in healthcare. CMAJ 2010;182:E839-842.

SUGGESTED CITATION FOR AGREE II PDF VERSION

AGREE Next Steps Consortium (2017). The AGREE II Instrument [Electronic version]. Retrieved , from http://www.agreetrust.org.

FUNDING
The development of the AGREE II Instrument was funded by a

grant from the Canadian Institutes of Health Research (FRN77822)

FOR FURTHER INFORMATION ABOUT THE AGREE II, PLEASE CONTACT
AGREE Project Office, agree@mcmaster.ca

AGREE Website, www.agreetrust.org

iii

AGREE NEXT STEPS CONSORTIUM MEMBERSHIP

Dr. Melissa C. Brouwers
Principal Investigator, AGREE Next Steps Consortium
McMaster University, Hamilton, Ontario, Canada

Consortium Members:
Dr. G.P. Browman, Victoria, British Columbia, Canada
Dr. J.S. Burgers, Dutch College of General Practitioners, Utrecht, The Netherlands
Dr. F. Cluzeau, Global Health and Development Group, Imperial College London, UK
Dr. D. Davis, Association of American Medical Colleges, Washington DC, USA
Dr. G. Feder, University of Bristol, UK
Dr. B. Fervers, Cancer et Environement, Centre Léon Bérard, France
Dr. I. Graham, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Dr. J. Grimshaw, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Dr. S.E. Hanna, McMaster University, Hamilton, Ontario, Canada
Ms. M.E. Kho, McMaster University, Hamilton, Ontario Canada
Dr. P. Littlejohns, Kings College London, UK
Ms. J. Makarski, Hamilton, Ontario, Canada
Dr. L. Zitzelsberger, Quebec, Canada

AGREE
II
VERSIONS
&
UPDATES

AGREE
II
Original
Public
Release
and
Publication
Date:
2009/2010

AGREE
II
Update:
September
2013

AGREE
II
Update:
December
2017

What’s
new
in
the
December
2017
update?

The
August
2017
update
includes
revisions
to
the
following
sections
of
the
Introduction:
‘AGREE
Website:

Resources
and
References’,
‘10
Years
of
AGREE’,
and
‘Scoring
the
AGREE
II’.
Guidance
has
been
added

regarding
the
use
of
AGREE
II
score
thresholds
to
distinguish
between
higher
and
lower
quality

guidelines.
In
addition,
minor
editorial
changes
have
been
made
throughout
the
Introduction
and
User’s

Manual.
The
content
of
the
AGREE
II
Instrument
itself
has
not
been
modified
since
2009
and
all
versions

of
the
AGREE
II
remain
valid
for
use.

TABLE OF CONTENTS

I. INTRODUCTION

I. Overview …………………………………………………………………………………………………………

II. Applying the AGREE II ………………………………………………………………………………. 3

III. AGREE Website: Resources and References …………………………………………………….. 3

IV. 10 Years of AGREE …………………………………………………………………………………………. 4

II. USER’S MANUAL: INSTRUCTIONS FOR USING THE AGREE II ………………………………….. 6

I. Preparing to Use the AGREE II …………………………………………………………………………. 7

II. Structure and Content of the AGREE II ………………………………………………………………. 7

III. Rating Scale and User’s Manual Sections ………………………………………………………….. 8

IV. Scoring the AGREE II ………………………………………………………………………………………. 9

V. Overall Assessment ……………………………………………………………………………………….. 10

VI. Guidance for Rating Each Item

a. Domain 1. Scope and Purpose …………………………………………………………………… 11

b. Domain 2. Stakeholder Involvement ……………………………………………………………. 15

c. Domain 3. Rigour of Development ……………………………………………………………… 19

d. Domain 4. Clarity of Presentation ……………………………………………………………….. 28

e. Domain 5. Applicability ……………………………………………………………………………… 32

f. Domain 6. Editorial Independence ……………………………………………………………… 37

g. Overall Guideline Assessment …………………………………………………………………… 40

III. AGREE II INSTRUMENT ………………………………………………………………………………………… 42

I. Domain 1. Scope and Purpose ……………………………………………………………………….. 43

II. Domain 2. Stakeholder Involvement ………………………………………………………………… 44

III. Domain 3. Rigour of Development …………………………………………………………………… 45

IV. Domain 4. Clarity of Presentation …………………………………………………………………….. 48

V. Domain 5. Applicability …………………………………………………………………………………… 49

VI. Domain 6. Editorial Independence …………………………………………………………………… 51

VII. Overall Guideline Assessment ………………………………………………………………………… 52

I. INTRODUCTION

I. OVERVIEW

i) Purpose of the AGREE II Instrument
Clinical practice guidelines (‘guidelines’) are systematically developed statements to assist
practitioner and patient decisions about appropriate health care for specific clinical
circumstances (1). In addition, guidelines can play an important role in health policy formation
(2,3) and have evolved to cover topics across the health care continuum (e.g., health promotion,
screening, diagnosis).

The potential benefits of guidelines are only as good as the quality of the guidelines themselves.
Appropriate methodologies and rigorous strategies in the guideline development process are
important for the successful implementation of the resulting recommendations (4-6). The quality
of guidelines can be extremely variable and some often fall short of basic standards (7-9).

The Appraisal of Guidelines for REsearch & Evaluation (AGREE) Instrument (10) was
developed to address the issue of variability in guideline quality. To that end, the AGREE
instrument is a tool that assesses the methodological rigour and transparency in which a
guideline is developed. The original AGREE instrument was refined, which resulted in the
AGREE II, and a User’s Manual was developed (11-13).

The purpose of the AGREE II, is to provide a framework to:

1. Assess the quality of guidelines;
2. Provide a methodological strategy for the development of guidelines; and
3. Inform what information and how information ought to be reported in guidelines.

The AGREE II replaces the original instrument as the preferred tool and can be used as part of
an overall quality mandate aimed to improve health care.

ii) History of the AGREE Project
The original AGREE Instrument was published in 2003 by a group of international guideline
developers and researchers, the AGREE Collaboration (10). The objective of the Collaboration
was to develop a tool to assess the quality of guidelines. The AGREE Collaboration defined
quality of guidelines as the confidence that the potential biases of guideline development have
been addressed adequately and that the recommendations are both internally and externally
valid, and are feasible for practice (10). The assessment includes judgments about the methods
used for developing the guidelines, the components of the final recommendations, and the
factors that are linked to their uptake. The result of the Collaboration’s effort was the original
AGREE Instrument, a 23-item tool comprising 6 quality domains. The AGREE Instrument has
been translated into many languages, has been cited in over 600 publications, and is endorsed
by several health care organizations. More details about the original instrument and related
publications are available on the AGREE Website (http://www.agreetrust.org/).

As with any new assessment tool, it was recognized that ongoing development was required to
strengthen the measurement properties of the instrument and to ensure its usability and
feasibility among intended users. This led several members of the original team to form the

AGREE Next Steps Consortium (Consortium). The objectives of the Consortium were to further
improve the measurement properties of the instrument, including its reliability and validity; to
refine the instrument’s items to better meet the needs of the intended users; and to improve the
supporting documentation (i.e., original training manual and user’s guide) to facilitate the ability
of users to implement the instrument with confidence.

The result of these efforts is the AGREE II, which is comprised of the new User’s Manual and 23
item tool organized into the same six domains, described here. The User’s Manual is a
significant modification of the original training manual and user’s guide and provides explicit
information for each of the 23 items. Table 1 compares the items of the original AGREE to the
items in the AGREE II.

Table 1. Comparison of the original AGREE and AGREE II items.

Original AGREE Item AGREE II Item

Domain 1. Scope and Purpose

1. The overall objective(s) of the guideline is (are)
specifically described.

No change

2. The clinical question(s) covered by the guideline is (are)
specifically described.

The health question(s) covered by the guideline is (are)
specifically described.

3. The patients to whom the guideline is meant to apply
are specifically described.

The population (patients, public, etc.) to whom the guideline is
meant to apply is specifically described.

Domain 2. Stakeholder Involvement

4. The guideline development group includes individuals
from all the relevant professional groups.

No change

5. The patients’ views and preferences have been sought. The views and preferences of the target population (patients,
public, etc.) have been sought.

6. The target users of the guideline are clearly defined. No change

7. The guideline has been piloted among end users. Delete item. Incorporated into user guide description of item
19.

Domain 3. Rigour of Development

8. Systematic methods were used to search for evidence. No change in item. Renumbered to 7.

9. The criteria for selecting the evidence are clearly
described.

No change in item. Renumbered to 8.

NEW Item 9. The strengths and limitations of the body of
evidence are clearly described.

10. The methods for formulating the recommendations are
clearly described.

No change

11. The health benefits, side effects, and risks have been
considered in formulating the recommendations.

No change

12. There is an explicit link between the recommendations
and the supporting evidence.

No change

13. The guideline has been externally reviewed by experts No change

Original AGREE Item AGREE II Item

prior to its publication.

14. A procedure for updating the guideline is provided. No change

Domain 4. Clarity of Presentation

15. The recommendations are specific and unambiguous. No change

16. The different options for management of the condition
are clearly presented.

The different options for management of the condition or health
issue are clearly presented.

17. Key recommendations are easily identifiable. No change

Domain 5. Applicability

18. The guideline is supported with tools for application. The guideline provides advice and/or tools on how the
recommendations can be put into practice.

AND Change in domain (from Clarity of Presentation) AND
renumbered to 19

19. The potential organizational barriers in applying the
recommendations have been discussed.

The guideline describes facilitators and barriers to its
application.

AND change in order – renumbered to 18

20. The potential cost implications of applying the
recommendations have been considered.

The potential resource implications of applying the
recommendations have been considered.

21. The guideline presents key review criteria for monitoring
and/ or audit purposes.

The guideline presents monitoring and/ or auditing criteria.

Domain 6. Editorial Independence

22. The guideline is editorially independent from the funding
body.

The views of the funding body have not influenced the content
of the guideline.

23. Conflicts of interest of guideline development members
have been recorded.

Competing interests of guideline development group members
have been recorded and addressed.

II. APPLYING THE AGREE II

i) Which guidelines can be appraised with the AGREE II?
As with the original instrument, the AGREE II is designed to assess guidelines developed by
local, regional, national or international groups or affiliated governmental organizations. These
include original versions of and updates of existing guidelines.

The AGREE II is generic and can be applied to guidelines in any health or disease area
targeting any step in the health care continuum, including those for health promotion, public
health, screening, diagnosis, treatment or interventions. It is suitable for guidelines presented in
paper or electronic format. The AGREE II has not been designed to assess the quality of
guidance documents that address health care organizational issues. Its role in the assessment
of health technology assessments has not been formally evaluated.

ii) Who can use the AGREE II?
The AGREE II is intended to be used by the following stakeholder groups:

• by health care providers who wish to undertake their own assessment of a guideline
before adopting its recommendations into their practice;

• by guideline developers to follow a structured and rigorous development methodology,
to conduct an internal assessment to ensure that their guidelines are sound, or to
evaluate guidelines from other groups for potential adaptation to their own context;

• by policy makers to help them decide which guidelines could be recommended for use
in practice or to inform policy decisions; and

• by educators to help enhance critical appraisal skills amongst health professionals and
to teach core competencies in guideline development and reporting.

III. AGREE WEBSITE: RESOURCES AND REFERENCES

The AGREE Enterprise website, www.agreetrust.org, contains a variety of tools to assist users
in applying the AGREE II.

i) Publications of AGREE Research

• Access publications related to the AGREE II and other AGREE tools.
• The Key publications: AGREE II page provides access to publications related to the

development and testing of the AGREE II.

ii) AGREE II Training Tools

• Two online tools are available to train new users of the AGREE II:
o AGREE II Overview Tutorial,
o AGREE II Practice Exercise.

iii) AGREE II Language Translations

• The AGREE II has been translated into various languages, thanks to members of the
international practice guideline community.

• Copies of these translations are available to the public on this webpage.
• If you would like to undertake a new translation, please contact the AGREE Project

Office by emailing agree@mcmaster.ca.

iv) My AGREE PLUS
• An online platform called My AGREE PLUS is freely available to the public to complete

and track AGREE II appraisals.
• The platform can be used to:

o Complete individual AGREE II appraisals,
o Contribute to a group AGREE II appraisal, and
o Coordinate a group AGREE II appraisal.

• Click the My AGREE PLUS tab at www.agreetrust.org to register and use the platform.

v) Other AGREE tools

• Access other AGREE tools to support the development, reporting and appraisal of
clinical practice guidelines and health systems guidance:

o AGREE Reporting Checklist: A checklist based on the AGREE II to guide the
reporting of clinical practice guidelines (14).

o AGREE GRS: A 4-item tool to assess the quality of clinical practice guidelines
when scarce time or resources make it unfeasible to use the more
comprehensive AGREE II.

o AGREE Recommendations Excellence (AGREE-REX): A tool to assess the
quality and direct the development and reporting of clinical practice guideline
recommendations.

o AGREE Health Systems (AGREE-HS): A tool to assess the quality and direct
the development and reporting of health systems guidance documents.

o CheckUp: A checklist to guide the reporting of updated clinical practice
guidelines (15).

IV. 10 Years of AGREE

In 2013, the AGREE Enterprise marked its 10th anniversary since the original AGREE
Instrument was first published and made available for use. To mark this anniversary, an article
was published summarizing the academic journey the AGREE instrument has taken, noting the
many accomplishments along the way (16).

REFERENCES
1. Woolf SH, Grol R, Hutchinson A, Eccles M, Grimshaw J. Clinical guidelines: potential

benefits, limitations, and harms of clinical guidelines. BMJ. 1999;318(7182):527-530.
2. Committee to Advise the Public Health Service on Clinical Practice Guidelines IoM. Clinical

practice guidelines: directions for a new program. Washington: National Academy Press;
1990.

3. Browman GP, Snider A, Ellis P. Negotiating for change. The healthcare manager as catalyst
for evidence-based practice: changing the healthcare environment and sharing experience.
Healthc Pap. 2003;3(3):10-22.

4. Grol R. Success and failures in the implementation of evidence-based guidelines for clinical
practice. Med Care. 2001;39(8 Suppl 2):1146-54.

5. Davis DA, Taylor-Vaisey A. Translating guidelines into practice: a systematic review of
theoretic concepts, practice experience and research evidence in the adoption of clinical
practice guidelines. CMAJ. 1997;157(4):408-16.

6. Grimshaw J,.Russell I. Effect of clinical guidelines on medical practice: a systematic review
of rigorous evaluations. Lancet. 1993;342:1317-22.

7. Shaneyfelt TM, Mayo-Smith MF Rothwangl J. Are guidelines following guidelines? The
methodological quality of clinical practice guidelines in the peer-reviewed medical literature.
JAMA 1999:281(20):1900-5.

8. Grilli R, Magrini N, Penna A, Mura G, Liberati A. Practice guidelines developed by specialty
societies: the need for critical appraisal. Lancet. 2000;355:103-6.

9. Burgers JS, Fervers B, Haugh M, Brouwers M, Browman G, Phillip T, Cluzeau FA.
International assessment of the quality of clinical practice guidelines in oncology using the
Appraisal of Guidelines and Research and Evaluation Instrument. J Clin Oncol.
2004;22:2000-7.

10. AGREE Collaboration. Development and validation of an international appraisal instrument
for assessing the quality of clinical practice guidelines: the AGREE project. Qual Saf Health
Care. 2003;12(1):18-23.

11. Brouwers MC, Kho ME, Browman GP, Burgers JS, Cluzeau F, Feder G, Fervers B, Graham
ID, Grimshaw J, Hanna S, Littlejohns P, Makarski J, Zitzelsberger L, for the AGREE Next
Steps Consortium. AGREE II: advancing guideline development, reporting and evaluation in
health care. CMAJ. 2010;182(18):E839-42.

12. Brouwers MC, Kho ME, Browman GP, Burgers JS, Cluzeau F, Feder G, Fervers B, Graham
ID, Hanna SE, Makarski J, for the AGREE Next Steps Consortium. Development of the
AGREE II, part 1: performance, usefulness and areas for improvement. CMAJ
2010;182(10):1045-52.

13. Brouwers MC, Kho ME, Browman GP, Burgers J, Cluzeau F, Feder G, Fervers B, Graham
ID, Hanna SE, Makarski J, for the AGREE Next Steps Consortium. Development of the
AGREE II, part 2: assessment of validity of items and tools to support application. CMAJ
2010;182(10):E472-8.

14. Brouwers MC, Kerkvliet K, Spithoff K, on behalf of the AGREE Next Steps Consortium. The
AGREE Reporting Checklist: A tool to improve reporting of clinical practice guidelines. BMJ
2016;352:i1152.

15. Vernooij RWM, Alonso-Coello P, Brouwers M, Martinez Garcia L, CheckUp Panel. Reporting
items for updated clinical guidelines: Checklist for the Reporting of Updated Guidelines
(CheckUp). PLOS Medicine 2017;14(1):e1002207.

16. Makarski J, Brouwers MC. The AGREE Enterprise: a decade of advancing clinical practice
guidelines. Implement Sci. 2014;9:103.

AGREE II:

USER’S MANUAL

II. USER’S MANUAL: INSTRUCTIONS FOR USING THE AGREE II

This User’s Manual has been designed specifically to guide appraisers in the use of the
instrument. We suggest reading the following instructions before using the instrument.

I. Preparing to Use the AGREE II

i) Accompanying Guideline Documents
Before applying the AGREE II, users should first carefully read the guideline document in full. In
addition to the guideline document, users should attempt to identify all information about the
guideline development process prior to the appraisal. This information may be contained in the
same document as the guideline recommendations or it may be summarized in a separate
technical report, methodological manual or guideline developer policy statement. These
supporting documents may be published or may be available publicly on web sites. While it is
the responsibility of the guideline authors to advise readers on the existence and location of
relevant additional technical and supporting documents, every effort should be made by the
AGREE II users to locate and include them as part of the materials appropriate for assessment.

ii) Number of Appraisers
We recommend that each guideline be assessed by at least 2 appraisers, and preferably 4, as
this will increase the reliability of the assessment.

II. Structure and Content of the AGREE II

The AGREE II consists of 23 key items organized within 6 domains followed by 2 global rating
items (“Overall Assessment”). Each domain captures a unique dimension of guideline quality.

Domain 1. Scope and Purpose is concerned with the overall aim of the guideline, the specific
health questions, and the target population (items 1-3).

Domain 2. Stakeholder Involvement focuses on the extent to which the guideline was developed
by the appropriate stakeholders and represents the views of its intended users (items 4-6).

Domain 3. Rigour of Development relates to the process used to gather and synthesize the
evidence, the methods to formulate the recommendations, and to update them (items 7-14).

Domain 4. Clarity of Presentation deals with the language, structure, and format of the guideline
(items 15-17).

Domain 5. Applicability pertains to the likely barriers and facilitators to implementation,
strategies to improve uptake, and resource implications of applying the guideline (items 18-21).

Domain 6. Editorial Independence is concerned with the formulation of recommendations not
being unduly biased with competing interests (items 22-23).

Overall assessment includes the rating of the overall quality of the guideline and whether the
guideline would be recommended for use in practice.

III. Rating Scale and User’s Manual Sections

Each of the AGREE II items and the two global rating items are rated on a 7-point scale (1–
strongly disagree to 7–strongly agree). The User’s Manual provides guidance on how to rate
each item using the rating scale and also includes 3 additional sections to further facilitate the
user’s assessment. The sections include User’s Manual Description, Where to Look, and How
to Rate.

i) Rating Scale
All AGREE II items are rated on the following 7-point scale:

Strongly Disagree 2 3 4 5 6
7

Strongly Agree

Score of 1 (Strongly Disagree). A score of 1 should be given when there is no information that is
relevant to the AGREE II item, if the concept is very poorly reported, or if the authors state
explicitly that criteria were not met.

Score of 7 (Strongly Agree). A score of 7 should be given if the quality of reporting is
exceptional and where the full criteria and considerations articulated in the User’s Manual have
been met.

Scores between 2 and 6. A score between 2 and 6 is assigned when the reporting of the
AGREE II item does not meet the full criteria or considerations. A score is assigned depending
on the completeness and quality of reporting. Scores increase as more criteria are met and
considerations addressed. The “How to Rate” section for each item includes details about
assessment criteria and considerations specific to the item.

ii) User’s Manual Description
This section defines the concept underlying the item in broad terms and provides examples.

iii) Where to Look
This section directs the appraiser to where the information in the guideline can usually be found.
Included in this section are common terms used to label guideline sections or chapters. These
are suggestions only. It is the responsibility of the appraiser to review the entire guideline and
accompanying material(s) to ensure a fair evaluation.

iv) How to Rate
This section includes details about assessment criteria and considerations specific to each item.

• The criteria identify explicit elements that reflect the operational definition
of the item. The more criteria that are met, the higher the score the
guideline should receive on that item.

• The considerations are aimed to help inform the assessment. As in any
evaluation, judgments by the appraisers are required. The more the
considerations have been taken into account in the guideline, the higher
the score the guideline should receive on that item.

It is important to note that guideline ratings require a level of judgment. The criteria and
considerations are there to guide, not to replace, these judgments. Thus, none of the AGREE II
items provide explicit expectations for each of the 7 points on the scale.

v) Other Considerations when Applying the AGREE II
On occasion, some AGREE II items may not be applicable to the particular guideline under
review. For example, guidelines narrow in scope may not provide the full range of options for
the management of the condition (see item 16). The AGREE II does not include a “Not
Applicable” response item in its scale. There are different strategies to manage this situation
including having appraisers skip that item in the assessment process or rating the item as 1
(absence of information) and providing context about the score. Regardless of strategy chosen,
decisions should be made in advance, described in an explicit manner, and if items are skipped,
appropriate modifications to calculating the domain scores should be implemented. As a
principle, excluding items in the appraisal process is discouraged.

IV. Scoring the AGREE II

A quality score is calculated for each of the six AGREE II domains. The six domain scores are
independent and should not be aggregated into a single quality score.

i) Calculating Domain Scores
Domain scores are calculated by summing up all the scores of the individual items in a domain
and by scaling the total as a percentage of the maximum possible score for that domain.

Example:

If 4 appraisers give the following scores for Domain 1 (Scope & Purpose):

Item 1 Item 2 Item 3 Total

Appraiser
1

5 6 6 17

Appraiser
2

6 6 7 19

Appraiser
3

2 4 3 9

Appraiser
4

3 3 2 8

Total 16 19 18 53
Appraiser

Maximum possible score = 7 (strongly agree) x 3 (items) x 4 (appraisers) = 84
Minimum possible score = 1 (strongly disagree) x 3 (items) x 4 (appraisers) = 12

The scaled domain score will be:

Obtained score – Minimum possible score

Maximum possible score – Minimum possible score

53 – 12 X 100 = 41 X 100 = 0.5694 x 100 = 57 % 84 – 12 72

If items are not included, appropriate modifications to the calculations of maximum and
minimum possible scores are required.

ii) Interpreting Domain Scores

Domain scores can be used to identify strengths and limitations of guidelines, to compare
methodological quality between guidelines, or to select high quality guidelines for adaptation,
endorsement, or implementation. At present, there are no empirical data to link specific quality
scores with specific implementation outcomes (e.g., speed of adoption, spread of adoption) or
specific clinical outcomes; this makes selection of quality thresholds to differentiate between
high, moderate, and low quality guidelines a challenge. In the absence of these data, we
provide examples of approaches that can be used to set quality thresholds:

• Prioritizing one domain: Through consensus or based on decisions by leadership, one
quality domain may be prioritized over the others. Thus, thresholds can be created
based on scores for the prioritized domain (e.g., high quality guidelines are those with a
Domain 3 score >70%).

• Staged AGREE II appraisal: If users value one domain over the others, they can first
appraise the guidelines using that domain only. Only those guidelines that meet a quality
threshold for that domain (e.g., >70%) are then appraised using the other five AGREE II
domains.

• Considering all domain scores: Users can create a threshold across all six domain
scores based on consensus or decisions by leadership (e.g., high quality guidelines are
those with domain scores that are all >70%). Alternatively, users might create different
thresholds for each of the domains.

• Thresholds for improvement over time: If evaluating changes in scores for guidelines
over time, users can create thresholds for improvement (e.g., at least 10% improvement
in each domain score for guidelines by a particular developer over a period of five
years).

Any decisions about how to define quality thresholds should be made by a panel of all relevant
stakeholders before beginning the AGREE II appraisals. Decisions should be guided by the
context in which the guideline is to be used and by evaluating the importance of the different
domains and items in that context.

V. Overall Assessment

Upon completing the 23 items, AGREE II users will provide 2 overall assessments of the
guideline. The overall assessment requires the user to make a judgment as to the quality of the
guideline, taking into account the criteria considered in the assessment process. The user is
also asked whether he/she would recommend use of the guideline.

________________________________________________________________________________________

The next pages include, by domain, guidance for rating each of the 23 items of the AGREE II
when appraising a guideline. Each item includes a description, suggestions for where to find the
item information, and guidance for how to rate.

DOMAIN 1. SCOPE AND PURPOSE

1. The overall objective(s) of the guideline is (are) specifically described.
2. The health question(s) covered by the guideline is (are) specifically

described.
3. The population (patients, public, etc.) to whom the guideline is meant

to apply is specifically described.

SCOPE AND PURPOSE

1. The overall objective(s) of the guideline is (are) specifically described.

1
Strongly Disagree 2 3 4 5 6

7
Strongly Agree

Comments

User’s Manual Description:
This deals with the potential health impact of a guideline on society and populations of patients or individuals.
The overall objective(s) of the guideline should be described in detail and the expected health benefits from the
guideline should be specific to the clinical problem or health topic. For example, specific statements would be:

• Preventing (long term) complications of patients with diabetes mellitus
• Lowering the risk of subsequent vascular events in patients with previous myocardial infarction
• Most effective population-based colorectal screening strategies
• Providing guidance on the most effective therapeutic treatment and management of patients with diabetes
mellitus.

Where to Look:
Examine the opening paragraphs/chapters for a description of the scope and purpose of the guideline. In some
cases, the rationale or need for the guideline is described in a document separate from the guideline, for
instance, in the guideline proposal. Examples of commonly labeled sections or chapters in a guideline where
this information can be found include: introduction, scope, purpose, rationale, background, and objectives.

How to Rate:
Item content includes the following CRITERIA:
• health intent(s) (i.e., prevention, screening, diagnosis, treatment, etc.)
• expected benefit or outcome
• target(s) (e.g., patient population, society)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?

SCOPE AND PURPOSE

2. The health question(s) covered by the guideline is (are) specifically described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
A detailed description of the health questions covered by the guideline should be provided, particularly for the
key recommendations (see Item 17), although they need not be phrased as questions. Following the examples
provided in question 1:
• How many times a year should the HbA1c be measured in patients with diabetes mellitus?
• What should the daily aspirin dosage for patients with proven acute myocardial infarction be?
• Does population-based colorectal screening using the fecal occult blood test reduce mortality of colorectal
cancer?
• Is self-monitoring effective for blood glucose control in patients with Type 2 diabetes?

Where to Look:
Examine the opening paragraphs/chapters for a description of the scope and purpose of the guideline. In some
cases, the questions are described in a document separate from the guideline, for instance in a search
specification. Examples of commonly labeled sections or chapters in a guideline where this information can be
found include: questions, scope, purpose, rationale, and background.

How to Rate:
Item content includes the following CRITERIA:
• target population
• intervention(s) or exposure(s)
• comparisons (if appropriate)
• outcome(s)
• health care setting or context

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is there enough information provided in the question(s) for anyone to initiate the development of a guideline
on this topic or to understand the patients/populations and contexts profiled in the guideline?

SCOPE AND PURPOSE

3. The population (patients, public, etc.) to whom the guideline is meant to apply
is specifically described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
A clear description of the population (i.e., patients, public, etc.) covered by a guideline should be provided. The
age range, sex, clinical description, and comorbidity may be provided. For example:

• A guideline on the management of diabetes mellitus only includes patients with non-insulin dependent
diabetes mellitus and excludes patients with cardiovascular comorbidity.
• A guideline on the management of depression only includes patients with major depression according to the
DSM-IV criteria, and excludes patients with psychotic symptoms and children.
• A guideline on screening of breast cancer only includes women, aged between 50 and 70 years, with no
history of cancer and with no family history of breast cancer.

Where to Look:
Examine the opening paragraphs/chapters for a description of the target population of the guideline. The
explicit exclusion of some populations (for instance children) is also covered by this item. Examples of
commonly labeled sections or chapters in a guideline where this information can be found include: patient
population, target population, relevant patients, scope, and purpose.

How to Rate:
Item content includes the following CRITERIA:
• target population, gender and age
• clinical condition (if relevant)
• severity/stage of disease (if relevant)
• comorbidities (if relevant)
• excluded populations (if relevant)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is the population information specific enough so that the correct and eligible individuals would receive
the action recommended in the guideline?

DOMAIN 2. STAKEHOLDER INVOLVEMENT

4. The guideline development group includes individuals from all
relevant professional groups.

5. The views and preferences of the target population (patients, public, etc.)
have been sought.

6. The target users of the guideline are clearly defined.

STAKEHOLDER INVOLVEMENT

4. The guideline development group includes individuals from all relevant
professional groups.

1
Strongly Disagree 2 3 4 5 6
7

Strongly Agree

Comments

User’s Manual Description:
This item refers to the professionals who were involved at some stage of the development process. This may
include members of the steering group, the research team involved in selecting and reviewing/rating the
evidence and individuals involved in formulating the final recommendations. This item excludes individuals who
have externally reviewed the guideline (see Item 13). This item excludes target population representation (see
Item 5). Information about the composition, discipline, and relevant expertise of the guideline development
group should be provided.

Where to Look:
Examine the opening paragraphs/chapters, acknowledgement section or appendices for the composition of the
guideline development group. Examples of commonly labeled sections or chapters in a guideline where this
information can be found include: methods, guideline panel member list, acknowledgements, and appendices.

How to Rate:
Item content includes the following CRITERIA:
• For each member of the guideline development group, the following information is included:

Ø name
Ø discipline/content expertise (e.g., neurosurgeon, methodologist)
Ø institution (e.g., St. Peter’s hospital)
Ø geographical location (e.g., Seattle, WA)
Ø a description of the member’s role in the guideline development group

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Are the members an appropriate match for the topic and scope? Potential candidates include relevant
clinicians, content experts, researchers, policy makers, clinical administrators, and funders.
• Is there at least one methodology expert included in the development group (e.g., systematic review expert,
epidemiologist, statistician, library scientist, etc.)?

STAKEHOLDER INVOLVEMENT

5. The views and preferences of the target population (patients, public, etc.) have
been sought.
preferences have been sought.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Information about target population experiences and expectations of health care should inform the
development of guidelines. There are various methods for ensuring that these perspectives inform the different
stages of guideline development by stakeholders. For example, formal consultations with patients/public to
determine priority topics, participation of these stakeholders on the guideline development group, or external
review by these stakeholders on draft documents. Alternatively, information could be obtained from interviews
of these stakeholders or from literature reviews of patient/public values, preferences or experiences. There
should be evidence that some process has taken place and that stakeholders’ views have been considered.

Where to Look:
Examine the paragraphs on the guideline development process. Examples of commonly labeled sections or
chapters in a guideline where this information can be found include: scope, methods, guideline panel member
list, external review, and target population perspectives.

How to Rate:
Item content includes the following CRITERIA:
• statement of type of strategy used to capture patients’/public’s’ views and preferences (e.g., participation in
the guideline development group, literature review of values and preferences)
• methods by which preferences and views were sought (e.g., evidence from literature, surveys, focus groups)
• outcomes/information gathered on patient/public information
• description of how the information gathered was used to inform the guideline development process and/or
formation of the recommendations

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?

STAKEHOLDER INVOLVEMENT

6. The target users of the guideline are clearly defined.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
The target users should be clearly defined in the guideline, so the reader can immediately determine if the
guideline is relevant to them. For example, the target users for a guideline on low back pain may include
general practitioners, neurologists, orthopaedic surgeons, rheumatologists, and physiotherapists.

Where to Look:
Examine the opening paragraphs/chapters for a description of the target users of the guideline. Examples of
commonly labeled sections or chapters in a guideline where this information can be found include: target user
and intended user.

How to Rate:
Item content includes the following CRITERIA:
• clear description of intended guideline audience (e.g. specialists, family physicians, patients, clinical or
institutional leaders/administrators)
• description of how the guideline may be used by its target audience (e.g., to inform clinical decisions, to
inform policy, to inform standards of care)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Are the target users appropriate for the scope of the guideline?

DOMAIN 3.

RIGOUR OF DEVELOPMENT

7. Systematic methods were used to search for evidence.
8. The criteria for selecting the evidence are clearly described.
9. The strengths and limitations of the body of evidence are clearly

described.
10. The methods for formulating the recommendations are clearly

described.
11. The health benefits, side effects, and risks have been considered in

formulating the recommendations.
12. There is an explicit link between the recommendations and the

supporting evidence.
13. The guideline has been externally reviewed by experts prior to its

publication.
14. A procedure for updating the guideline is provided.

RIGOUR OF DEVELOPMENT

7. Systematic methods were used to search for evidence.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Details of the strategy used to search for evidence should be provided including search terms used, sources
consulted, and dates of the literature covered. Sources may include electronic databases (e.g. MEDLINE,
EMBASE, CINAHL), databases of systematic reviews (e.g. the Cochrane Library, DARE), handsearching
journals, reviewing conference proceedings, and other guidelines (e.g. the US National Guideline
Clearinghouse, the German Guidelines Clearinghouse). The search strategy should be as comprehensive as
possible and executed in a manner free from potential biases and sufficiently detailed to be replicated.

Where to Look:
Examine the paragraphs/chapters describing the guideline development process. In some cases the search
strategies are described in separate documents or in an appendix to the guideline. Examples of commonly
labelled sections or chapters in a guideline where this information can be found include: methods, literature
search strategy, and appendices.

How to Rate:
Item content includes the following CRITERIA:
• named electronic database(s) or evidence source(s) where the search was performed (e.g., MEDLINE,
EMBASE, PsychINFO, CINAHL)
• time periods searched (e.g., January 1, 2004 to March 31, 2008)
• search terms used (e.g., text words, indexing terms, subheadings)
• full search strategy included (e.g., possibly located in appendix)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is the search relevant and appropriate to answer the health question? (e.g., all relevant databases and,
appropriate search terms used)
• Is there enough information provided for anyone to replicate the search?

RIGOUR OF DEVELOPMENT

8. The criteria for selecting the evidence are clearly described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Criteria for including/excluding evidence identified by the search should be provided. These criteria should be
explicitly described and reasons for including and excluding evidence should be clearly stated. For example,
guideline authors may decide to only include evidence from randomized clinical trials and to exclude articles
not written in English.

Where to Look:
Examine the paragraphs/chapters describing the guideline development process. In some cases, the inclusion
or exclusion criteria for selecting the evidence are described in separate documents or in an Appendix to the
guideline. Examples of commonly labeled sections or chapters in a guideline where this information can be
found include: methods, literature search, inclusion/exclusion criteria, and appendices.

How to Rate:
Item content includes the following CRITERIA:
• description of the inclusion criteria, including

Ø target population (patient, public, etc.) characteristics
Ø study design
Ø comparisons (if relevant)
Ø outcomes
Ø language (if relevant)
Ø context (if relevant)

• description of the exclusion criteria (if relevant; e.g., French only listed in the inclusion criteria statement could
logically preclude non-French listed in the exclusion criteria statement)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is there a rationale given for the chosen inclusion/exclusion criteria?
• Do inclusion/exclusion criteria align with the health question(s)?
• Are there reasons to believe that relevant literature may not have been considered?

RIGOUR OF DEVELOPMENT

9. The strengths and limitations of the body of evidence are clearly described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Statements highlighting the strengths and limitations of the evidence should be provided. This ought to include
explicit descriptions – using informal or formal tools/methods – to assess and describe the risk of bias for
individual studies and/or for specific outcomes and/or explicit commentary of the body of evidence aggregated
across all studies. This may be presented in different ways, for example: using tables commenting on different
quality domains; the application of a formal instrument or strategy (e.g., Jadad scale, GRADE method); or
descriptions in the text.

Where to Look:
Examine the paragraphs/chapters describing the guideline development process for information on how the
methodological quality of the studies (e.g., risk of bias) were described. Evidence tables are often used to
summarize quality features. Some guidelines make a clear distinction between description and interpretation of
evidence, for instance, in a results section and a discussion section, respectively.

How to Rate:
Item content includes the following CRITERIA:
• descriptions of how the body of evidence was evaluated for bias and how it was interpreted by members of
the guideline development group

• aspects upon which to frame descriptions include:
Ø study design(s) included in body of evidence
Ø study methodology limitations (sampling, blinding, allocation concealment, analytical methods)
Ø appropriateness/relevance of primary and secondary outcomes considered
Ø consistency of results across studies
Ø direction of results across studies
Ø magnitude of benefit versus magnitude of harm
Ø applicability to practice context

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Are the descriptions appropriate, neutral, and unbiased? Are the descriptions complete?

RIGOUR OF DEVELOPMENT

10. The methods for formulating the recommendations are clearly described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
A description of the methods used to formulate the recommendations and how final decisions were arrived at
should be provided. For example, methods may include a voting system, informal consensus, and formal
consensus techniques (e.g., Delphi, Glaser techniques). Areas of disagreement and methods of resolving them
should be specified.

Where to Look:
Examine the paragraphs/chapters describing the guideline development process. In some cases, the methods
used to formulate the recommendations are described in separate documents or in an appendix to the
guideline. Examples of commonly labeled sections or chapters in a guideline where this information can be
found include methods and guideline development process.

How to Rate:
Item content includes the following CRITERIA:
• description of the recommendation development process (e.g., steps used in modified Delphi technique,
voting procedures that were considered)
• outcomes of the recommendation development process (e.g., extent to which consensus was reached using
modified Delphi technique, outcome of voting procedures)
• description of how the process influenced the recommendations (e.g., results of Delphi technique influence
final recommendation, alignment with recommendations and the final vote)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Was a formal process used to arrive at the recommendations?
• Were the methods appropriate?

RIGOUR OF DEVELOPMENT

11. The health benefits, side effects, and risks have been considered in
formulating the recommendations.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
The guideline should consider health benefits, side effects, and risks when formulating the recommendations.
For example, a guideline on the management of breast cancer may include a discussion on the overall effects
on various final outcomes. These may include: survival, quality of life, adverse effects, and symptom
management or a discussion comparing one treatment option to another. There should be evidence that these
issues have been addressed.

Where to Look:
Examine the paragraphs/chapters describing the guideline development process for a description of the body
of evidence, its interpretation, and the translation to practice recommendations. Examples of commonly labeled
sections or chapters in a guideline where this information can be found include: methods, interpretation,
discussion, and recommendations.

How to Rate:
Item content includes the following CRITERIA:
• supporting data and report of benefits
• supporting data and report of harms/side effects/risks
• reporting of the balance/trade-off between benefits and harms/side effects/risks
• recommendations reflect considerations of both benefits and harms/side effects/risks

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is the discussion an integral part of the guideline development process? (i.e., taking place during
recommendation formulation rather than post-formulation as an afterthought)
• Has the guideline development group considered the benefits and harms equally?

RIGOUR OF DEVELOPMENT

12. There is an explicit link between the recommendations and the supporting
evidence.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
An explicit link between the recommendations and the evidence on which they are based should be included in
the guideline. The guideline user should be able to identify the components of the body of evidence relevant to
each recommendation.

Where to Look:
Define and examine the recommendations in the guideline and the text describing the body of evidence that
underpins them. Examples of commonly labeled sections or chapters in a guideline where this information can
be found include: recommendations and key evidence.

How to Rate:
Item content includes the following CRITERIA:
• the guideline describes how the guideline development group linked and used the evidence to inform
recommendations
• each recommendation is linked to a key evidence description/paragraph and/or reference list
• recommendations linked to evidence summaries, evidence tables in the results section of the guideline

Additional CONSIDERATIONS:
• Is there congruency between the evidence and recommendations?
• Is the link between the recommendations and supporting evidence easy to find in the guideline?
• When evidence is lacking or a recommendation is informed primarily by consensus of opinion by the guideline
group, rather than the evidence, is this clearly stated and described?

RIGOUR OF DEVELOPMENT

13. The guideline has been externally reviewed by experts prior to its publication.

Strongly Disagree
2 3 4 5 6

7
Strongly Agree

Comments

User’s Manual Description:
A guideline should be reviewed externally before it is published. Reviewers should not have been involved in
the guideline development group. Reviewers should include experts in the clinical area as well as some
methodological experts. Target population (patients, public) representatives may also be included. A
description of the methodology used to conduct the external review should be presented, which may include a
list of the reviewers and their affiliation.

Where to Look:
Examine the paragraphs/chapters describing the guideline development process and the acknowledgement
section. Examples of commonly labeled sections or chapters in a guideline where this information can be found
include: methods, results, interpretation, and acknowledgements.

How to Rate:
Item content includes the following CRITERIA:
• purpose and intent of the external review (e.g., to improve quality, gather feedback on draft
recommendations, assess applicability and feasibility, disseminate evidence)
• methods taken to undertake the external review (e.g., rating scale, open-ended questions)
• description of the external reviewers (e.g., number, type of reviewers, affiliations)
• outcomes/information gathered from the external review (e.g., summary of key findings)
• description of how the information gathered was used to inform the guideline development process and/or
formation of the recommendations (e.g., guideline panel considered results of review in forming final
recommendations)

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Are the external reviewers relevant and appropriate to the scope of the guideline? Was there a rationale given
for choosing the included reviewers?
• How was information from the external review used by the guideline development group?

RIGOUR OF DEVELOPMENT

14. A procedure for updating the guideline is provided.

1
Strongly Disagree
2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Guidelines need to reflect current research. A clear statement about the procedure for updating the guideline
should be provided. For example, a timescale has been given or a standing panel is established who receives
regularly updated literature searches and makes changes as required.

Where to Look:
Examine the introduction paragraph, the paragraphs describing the guideline development process and the
closing paragraphs. Examples of commonly labeled sections or chapters in a guideline where this information
can be found include: methods, guideline update, and date of guideline.

How to Rate:
Item content includes the following CRITERIA:
• a statement that the guideline will be updated
• explicit time interval or explicit criteria to guide decisions about when an update will occur
• methodology for the updating procedure is reported

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is there enough information provided to know when an update will occur or what criteria would trigger an
update?

DOMAIN 4. CLARITY OF PRESENTATION

15. The recommendations are specific and unambiguous.
16. The different options for management of the condition or health issue

are clearly presented.
17. Key recommendations are easily identifiable.

CLARITY OF PRESENTATION

15. The recommendations are specific and unambiguous.

1
Strongly Disagree 2 3 4 5 6

7
Strongly Agree

Comments

User’s Manual Description:
A recommendation should provide a concrete and precise description of which option is appropriate in which
situation and in what population group, as informed by the body of evidence.
• An example of a specific recommendation is: Antibiotics should be prescribed in children two years or older
with a diagnosis of acute otitis media if the pain lasts longer than three days or if the pain increases after the
consultation despite adequate treatment with painkillers; in these cases, amoxicillin should be given for 7 days
(supplied with a dosage scheme).
• An example of a vague recommendation is: Antibiotics are indicated for cases with an abnormal or
complicated course.

It is important to note that in some instances, evidence is not always clear cut and there may be uncertainty
about the best care option(s). In this case, the uncertainty should be stated in the guideline.

Where to Look:
Define and examine the recommendations in the guideline. Examples of commonly labeled sections or
chapters in a guideline where this information can be found include: recommendations and executive summary.

How to Rate:
Item content includes the following CRITERIA:
• statement of the recommended action
• identification of the intent or purpose of the recommended action (e.g., to improve quality of life, to decrease
side effects)
• identification of the relevant population (e.g., patients, public)
• caveats or qualifying statements, if relevant (e.g., patients or conditions for whom the recommendations
would not apply)

Additional CONSIDERATIONS:
• In the event of multiple recommendations (e.g., management guidelines), is there clarity regarding to whom
each recommendation applies?
• If there is uncertainty in the interpretation and discussion of the evidence, is the uncertainty reflected in the
recommendations and explicitly stated?

CLARITY OF PRESENTATION

16. The different options for management of the condition or health issue are
clearly presented.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
A guideline that targets the management of a disease should consider the different possible options for
screening, prevention, diagnosis or treatment of the condition it covers. These possible options should be
clearly presented in the guideline.
For example, a recommendation on the management of depression may contain the following treatment
alternatives:
a. Treatment with TCA
b. Treatment with SSRI
c. Psychotherapy
d. Combination of pharmacological and psychological therapy

Where to Look:
Examine the recommendations and their supporting evidence. Examples of commonly labeled sections or
chapters in a guideline where this information can be found include: executive summary, recommendations,
discussion, treatment options, and treatment alternatives.

How to Rate:
Item content includes the following CRITERIA:
• description of options
• description of population or clinical situation most appropriate to each option

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is this pertaining to a guideline broad or narrow in scope? This item may be more relevant to guidelines that
are broad in scope (e.g., covering the management of a condition or issue rather than focusing on a particular
set of interventions for a specific condition/issue).

CLARITY OF PRESENTATION

17. Key recommendations are easily identifiable.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Users should be able to find the most relevant recommendations easily. These recommendations answer the
main question(s) that have been covered by the guideline and can be identified in different ways. For example,
they can be summarized in a box, typed in bold, underlined or presented as flow charts or algorithms.

Where to Look:
Examples of commonly labeled sections or chapters in a guideline where this information can be found include:
executive summary, conclusions, and recommendations. Some guidelines provide separate summaries with
key recommendations (e.g., quick reference guide).

How to Rate:
Item content includes the following CRITERIA:
• description of recommendations in a summarized box, typed in bold, underlined, or presented as flow charts
or algorithms
• specific recommendations are grouped together in one section

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Are the key recommendations appropriately selected and do they reflect the key messages of the guideline?
• Are specific recommendations grouped in a section placed near the summary of the key evidence?

DOMAIN 5. APPLICABILITY

18. The guideline describes facilitators and barriers to its application.
19. The guideline provides advice and/or tools on how the

recommendations can be put into practice.
20. The potential resource implications of applying the recommendations

have been considered.
21. The guideline presents monitoring and/or auditing criteria.

APPLICABILITY

18. The guideline describes facilitators and barriers to its application.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
There may be existing facilitators and barriers that will impact the application of guideline recommendations.
For example:
i. A guideline on stroke may recommend that care should be coordinated through stroke units and
stroke services. There may be a special funding mechanism in the region to enable the formation of stroke
units.
ii. A guideline on diabetes in primary care may require that patients are seen and followed up in
diabetic clinics. There may be an insufficient number of clinicians available in a region to enable clinics to be
established.

Where to Look:
Examine the paragraph/chapter on the dissemination/implementation of the guideline or, if available, additional
documents with specific plans or strategies for implementation of the guideline. Examples of commonly labeled
sections or chapters in a guideline where this information can be found include: barriers, guideline utilization,
and quality indicators.

How to Rate:
Item content includes the following CRITERIA:
• identification of the types of facilitators and barriers that were considered
• methods by which information regarding the facilitators and barriers to implementing recommendations were
sought (e.g., feedback from key stakeholders, pilot testing of guidelines before widespread implementation)
• information/description of the types of facilitators and barriers that emerged from the inquiry (e.g.,
practitioners have the skills to deliver the recommended care, sufficient equipment is not available to ensure all
eligible members of the population receive mammography)
• description of how the information influenced the guideline development process and/or formation of the
recommendations

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Does the guideline suggest specific strategies to overcoming the barriers?

APPLICABILITY

19. The guideline provides advice and/or tools on how the recommendations can
be put into practice.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
For a guideline to be effective it needs to be disseminated and implemented with additional materials.
For example, these may include: a summary document, a quick reference guide, educational tools, results from
a pilot test, patient leaflets, or computer support. Any additional materials should be provided with the guideline.

Where to Look:
Examine the paragraph on the dissemination/implementation of the guideline and, if available, the specific
accompanying materials that have been produced to support the dissemination and implementation of the
guideline. Examples of commonly labeled sections or chapters in a guideline where this information can be
found include: tools, resources, implementation, and appendices.

How to Rate:
Item content includes the following CRITERIA:
• an implementation section in the guideline
• tools and resources to facilitate application:

Ø guideline summary documents
Ø links to check lists, algorithms
Ø links to how-to manuals
Ø solutions linked to barrier analysis (see Item 18)
Ø tools to capitalize on guideline facilitators (see Item 18)
Ø outcome of pilot test and lessons learned

• directions on how users can access tools and resources

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Is there information about the development of the implementation tools and validation procedures?

APPLICABILITY

20. The potential resource implications of applying the recommendations have
been considered.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
The recommendations may require additional resources in order to be applied. For example, there may be a
need for more specialized staff, new equipment, and expensive drug treatment. These may have cost
implications for health care budgets. There should be a discussion in the guideline of the potential impact of the
recommendations on resources.

Where to Look:
Examine the paragraph(s) on the dissemination/implementation of the guideline or, if available, additional
documents with specific plans or strategies for implementation of the guideline. Some guidelines present cost
implications in the paragraphs that discuss the evidence or decisions behind the recommendations. Examples
of commonly labeled sections or chapters in a guideline where this information can be found include: methods,
cost utility, cost effectiveness, acquisition costs, and implications for budgets.

How to Rate:
Item content includes the following CRITERIA:
• identification of the types of cost information that were considered (e.g., economic evaluations, drug
acquisition costs)
• methods by which the cost information was sought (e.g., a health economist was part of the guideline
development panel, use of health technology assessments for specific drugs, etc.)
• information/description of the cost information that emerged from the inquiry (e.g., specific drug acquisition
costs per treatment course)
• description of how the information gathered was used to inform the guideline development process and/or
formation of the recommendations

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• Were appropriate experts involved in finding and analyzing the cost information?

APPLICABILITY

21. The guideline presents monitoring and/or auditing criteria.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Measuring the application of guideline recommendations can facilitate their ongoing use. This requires clearly
defined criteria that are derived from the key recommendations in the guideline. The criteria may include
process measures, behavioural measures, clinical or health outcome measures. Examples of monitoring and
audit criteria are:
• The HbA1c should be < 8.0%. • The level of diastolic blood pressure should be < 95 mmHg. • 80% of the population aged 50 years should receive colorectal cancer screening rates using fecal occult blood tests. • If complaints of acute otitis media last longer than three days, amoxicillin should be prescribed. Where to Look: Examine the paragraph/chapter on auditing or monitoring the use of the guideline or, if available, additional documents with specific plans or strategies for evaluation of the guideline. Examples of commonly labeled sections or chapters in a guideline where this information can be found include: recommendations, quality indicators, and audit criteria. How to Rate: Item content includes the following CRITERIA: • identification of criteria to assess guideline implementation or adherence to recommendations • criteria for assessing impact of implementing the recommendations • advice on the frequency and interval of measurement • descriptions or operational definitions of how the criteria should be measured Additional CONSIDERATIONS: • Is the item well written? Are the descriptions clear and concise? • Is the item content easy to find in the guideline? • Are a range of criteria provided including process measures, behavioural measures, and clinical or health outcomes?

DOMAIN 6. EDITORIAL INDEPENDENCE

22. The views of the funding body have not influenced the content of the
guideline.

23. Competing interests of guideline development group members have
been recorded and addressed.

EDITORIAL INDEPENDENCE

22. The views of the funding body have not influenced the content of the
guideline.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
Many guidelines are developed with external funding (e.g., government, professional associations, charity
organizations, pharmaceutical companies). Support may be in the form of financial contribution for the
complete development, or for parts of it (e.g., printing of the guidelines). There should be an explicit statement
that the views or interests of the funding body have not influenced the final recommendations.

Where to Look:
Examine the paragraphs/chapters on the guideline development process or acknowledgements section.
Examples of commonly labeled sections or chapters in a guideline where this information can be found include:
disclaimer and funding source.

How to Rate:
Item content includes the following CRITERIA:
• the name of the funding body or source of funding (or explicit statement of no funding)
• a statement that the funding body did not influence the content of the guideline

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• How did the guideline development group address potential influence from the funding body?

EDITORIAL INDEPENDENCE

23. Competing interests of guideline development group members have been
recorded and addressed.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

User’s Manual Description:
There are circumstances when members of the development group may have competing interests. For
example, this would apply to a member of the development group whose research on the topic covered by the
guideline is also funded by a pharmaceutical company. There should be an explicit statement that all group
members have declared whether they have any competing interests.

Where to Look:
Examine the paragraphs/chapters describing the guideline development group or acknowledgements section.
Examples of commonly labeled sections or chapters in a guideline where this information can be found include:
methods, conflicts of interest, guideline panel, and appendix.

How to Rate:
Item content includes the following CRITERIA:
• description of the types of competing interests considered
• methods by which potential competing interests were sought
• description of the competing interests
• description of how the competing interests influenced the guideline process and development of
recommendations

Additional CONSIDERATIONS:
• Is the item well written? Are the descriptions clear and concise?
• Is the item content easy to find in the guideline?
• What measures were taken to minimize the influence of competing interests on guideline development or
formulation of the recommendations?

OVERALL GUIDELINE ASSESSMENT

For each question, please choose the response which best characterizes the guideline
assessed:

1. Rate the overall quality of this guideline.

1
Lowest possible

quality
2 3 4 5 6

7
Highest possible

quality

2. I would recommend this guideline for use.

Yes

Yes, with modifications

NOTES

User’s Manual Description:
The overall assessment requires the AGREE II user to make a judgment as to the quality of the guideline,
taking into account the appraisal items considered in the assessment process.

AGREE II INSTRUMENT

DOMAIN 1. SCOPE AND PURPOSE

1. The overall objective(s) of the guideline is (are) specifically described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

2. The health question(s) covered by the guideline is (are) specifically described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

3. The population (patients, public, etc.) to whom the guideline is meant to apply is
specifically described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 2. STAKEHOLDER INVOLVEMENT

views and preferences have been sought.

4. The guideline development group includes individuals from all relevant professional
groups.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

5. The views and preferences of the target population (patients, public, etc.) have been
sought.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

6. The target users of the guideline are clearly defined.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 3. RIGOUR OF DEVELOPMENT

7. Systematic methods were used to search for evidence.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

8. The criteria for selecting the evidence are clearly described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

9. The strengths and limitations of the body of evidence are clearly described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 3. RIGOUR OF DEVELOPMENT continued

10. The methods for formulating the recommendations are clearly described.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

11. The health benefits, side effects, and risks have been considered in formulating the
recommendations.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

12. There is an explicit link between the recommendations and the supporting
evidence.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 3. RIGOUR OF DEVELOPMENT continued

13. The guideline has been externally reviewed by experts prior to its publication.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

14. A procedure for updating the guideline is provided.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 4. CLARITY OF PRESENTATION

DOMAIN 5. APPLICABILITY

15. The recommendations are specific and unambiguous.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

16. The different options for management of the condition or health issue are clearly
presented.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

17. Key recommendations are easily identifiable.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 5. APPLICABILITY

18. The guideline describes facilitators and barriers to its application.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

19. The guideline provides advice and/or tools on how the recommendations can be
put into practice.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

20. The potential resource implications of applying the recommendations have been
considered.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 5. APPLICABILITY continued

DOMAIN 6. EDITORIAL INDEPENDENCE

21. The guideline presents monitoring and/or auditing criteria.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

DOMAIN 6. EDITORIAL INDEPENDENCE

22. The views of the funding body have not influenced the content of the guideline.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

23. Competing interests of guideline development group members have been recorded
and addressed.

1
Strongly Disagree 2 3 4 5 6
7
Strongly Agree

Comments

OVERALL GUIDELINE ASSESSMENT

For each question, please choose the response which best characterizes the guideline
assessed:

1. Rate the overall quality of this guideline.
1
Lowest possible
quality
2 3 4 5 6
7
Highest possible
quality

2. I would recommend this guideline for use.

Yes
Yes, with modifications
No

NOTES

DNP-820 AGREE II Instrument Table

Link to selected practice guideline:

Rationale behind choosing the guideline:

For each item, choose the rating that best characterizes the guideline assessed.

Domain

Item

Rating

Strongly Disagree

Strongly Agree

Scope and Purpose

1. The overall objective(s) of the guideline is(are) specifically described.

2. The health question(s) covered by the guideline is(are) specifically described.

3. The population (patient, public, etc.) to whom the guideline is meant to apply is specifically described.

Comments

Stakeholder Involvement

4. The guideline development group includes individuals from all relevant professional groups.

5. The views and preferences of the target population (patients, public, etc.) have been sought.

6. The target users of the guideline are clearly defined.

Comments

Rigor of Development

7. Systematic methods were used to search for evidence.

8. The criteria for selecting the evidence are clearly described.

9. The strengths and limitations of the body of evidence are clearly described.

10. The methods for formulating the recommendations are clearly described.

11. The health benefits, side effects, and risks have been considered in formulating the recommendations.

12. There is an explicit link between the recommendations and the supporting evidence.

13. The guideline has been externally reviewed by experts prior to its publication.

14. A procedure for updating the guideline is provided.

Comments

Clarity of Presentation

15. The recommendations are specific and unambiguous.

16. The different options for management of the condition or health issue are clearly presented.

17. Key recommendations are easily identifiable.

Comments

Applicability

18. The guideline describes facilitators and barriers to its application.

19. The guideline provides advice or tools to put the recommendations into practice.

20. The potential resource implications of applying the recommendations have been considered.

21. The guideline presents monitoring or auditing criteria.

Comments

Editorial Independence

22. The views of the funding body have not influenced the content of the guideline.

23. Competing interest of guideline development group members has been recorded and addressed.

Comments

Overall Guideline Assessment

1. Rate the overall quality of this guideline.

Lowest possible quality

Highest possible quality

2. I would recommend this guideline for use.

Yes

Yes, with modifications

Notes

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